SLU-PP-332 Oral: Scientific Profile
Publicado el · Actualizado el
Selective ERR-α receptor agonist for metabolic research. It activates mitochondrial biogenesis and increases fatty acid oxidation in skeletal muscle in preclinical models.
SLU-PP-332 is a small molecule classified as an agonist of the estrogen-related receptors (ERRs), with a predominant selectivity toward the ERR-α isoform. In the research setting, these receptors function as master regulators of the transcriptional networks responsible for energy homeostasis and mitochondrial function. Administration of this compound in laboratory models aims to mimic the molecular adaptations observed during sustained aerobic physical exercise.
The experimental findings indicate that SLU-PP-332 induces a transition in the phenotype of muscle fibers, promoting the development of slow-twitch fibers with high mitochondrial density. This biochemical change facilitates a greater dependence on the use of lipids as the primary energy substrate, which has shown significant effects on weight reduction without altering caloric intake in study subjects. The clinical relevance of this compound lies in its ability to influence systemic metabolism without the need for mechanical contractile activity.
The oral presentation of SLU-PP-332 allows evaluation of the bioavailability and pharmacokinetics of the molecule under a systemic dosing regimen. Current studies focus on its potential to mitigate metabolic dysfunction and improve mechanical endurance performance through the optimization of cellular oxidative capacity. It is an essential tool in the research of metabolic diseases and muscular dystrophies.
Mechanism of action
SLU-PP-332 acts as an agonist ligand of the ERR-α nuclear receptor, which coordinates with the coactivator PGC-1α to regulate the expression of genes involved in oxidative phosphorylation. Upon binding to the receptor, it promotes the expression of fatty-acid transporter proteins and Krebs cycle enzymes, resulting in an increase in mitochondrial respiration and non-shivering thermogenesis.
Mechanism summary
Selective ERR-α agonist that activates the PGC-1α/ERR signaling pathway to promote mitochondrial biogenesis and lipid oxidation.
Clinical Studies (6)
- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity (Billon, et al. · ACS Chemical Biology · 2023) PMID 36988910.
- A Synthetic ERR Agonist Alleviates Metabolic Syndrome (Billon, et al. · Journal of Pharmacology and Experimental Therapeutics · 2024) PMID 37739806.
- Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function (Xu, et al. · Circulation · 2024) PMID 37961903.
- In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. (Möller T, et al. · Rapid Commun Mass Spectrom · 2026) PMID 41588687.
- Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes. (Avliyakulov NK, et al. · Drug Test Anal · 2026) PMID 41688415.
- Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling. (Okda HE, et al. · Int J Biol Macromol · 2026) PMID 41850449.
Warnings
SLU-PP-332 Oral is a research-use-only (RUO) compound; the following warnings and handling considerations apply to its laboratory use:
- Exclusive use for research in controlled settings
- Its long-term safety profile has not been determined
- Caution in models with preexisting thyroid function pathologies
- Research models with acute renal insufficiency
- Subjects with a history of hormone-sensitive neoplasms
- Research related to gestation or lactation processes
Technical data
- CAS
- 303760-60-3
- Molecular formula
- C18H14N2O2
- Molecular weight
- 290.32 Da
- Compound type
- sarm
- Storage
- -20 °C liofilizado; en recipiente hermético
- Shelf life (lyophilized)
- 24 months
- Shelf life (reconstituted)
- Not applicable (Tablet/Capsule)
- Light-sensitive
- No
Frequently asked questions about SLU-PP-332 Oral
What is Oral SLU-PP-332?
Selective ERR-α receptor agonist for metabolic research. It activates mitochondrial biogenesis and increases fatty acid oxidation in skeletal muscle in preclinical models.
What is the mechanism of action of SLU-PP-332 Oral?
Selective ERR-α agonist that activates the PGC-1α/ERR signaling pathway to promote mitochondrial biogenesis and lipid oxidation.
What is SLU-PP-332 Oral investigated for?
In preclinical research, SLU-PP-332 Oral is studied mainly in: Modulation of mitochondrial oxidative metabolism; Research on weight reduction of metabolic origin; Study of the mimicking of adaptations to endurance exercise. Material exclusively for scientific research.
What are the chemical properties of SLU-PP-332 Oral?
Molecular formula C18H14N2O2; molecular weight 290.32 Da; CAS number 303760-60-3.
How is SLU-PP-332 Oral stored?
Condiciones de conservación: -20 °C liofilizado; en recipiente hermético; estabilidad liofilizado: 24 meses; una vez reconstituido: No aplica (Tablet/Cápsula).
What routes of administration are studied for SLU-PP-332 Oral?
In research models the following are described: Oral. Use is exclusively for scientific research.