Cock Bombs (Sildenafil 50 + Tadalafil 20): Scientific Profile
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Research compound that combines Sildenafil (50 mg) and Tadalafil (20 mg) in an oral formulation. It acts as a dual phosphodiesterase-5 (PDE5) inhibitor for studying its effect on vascular hemodynamics.
Cock Bombs is a research formulation designed to analyze the synergistic effects of two selective phosphodiesterase type 5 (PDE5) inhibitor agents. The combination of Sildenafil (50 mg) and Tadalafil (20 mg) allows the study of differentiated pharmacokinetic profiles, integrating a rapid, short-onset action together with a prolonged half-life. This compound is fundamental in protocols that analyze the regulation of blood flow and the relaxation of the vascular endothelium in experimental models of erectile dysfunction.
Sildenafil acts as an early-onset inhibitor, facilitating the investigation of rapid plasma peaks, while Tadalafil, with a half-life exceeding 17 hours, allows observation of long-range vascular stability. This duality is of special interest in the study of pulmonary arterial hypertension and Raynaud's phenomenon, where the persistence of cyclic guanosine monophosphate (cGMP) is critical for vascular homeostasis.
In laboratory settings, this compound is used to evaluate the modulation of nitric oxide (NO) signaling pathways. Inhibition of cGMP degradation by PDE5 results in a significant reduction of intracellular calcium levels in bronchial and vascular smooth muscle cells. Use of this mixture is strictly limited to in vitro scientific research or animal models to determine vasodilatory efficacy parameters.
Mechanism of action
The main mechanism consists of the selective inhibition of the PDE5 enzyme in the smooth muscle of the corpora cavernosa and the pulmonary vasculature. During the release of nitric oxide, PDE5 inhibition prevents the degradation of cGMP; this accumulation activates protein kinase G, which causes the dephosphorylation of myosin light chains and the sequestration of cytosolic calcium, facilitating sustained vasodilation and increased local blood flow.
Mechanism summary
Competitive and selective inhibition of the enzyme phosphodiesterase type 5, enhancing cGMP signaling to induce relaxation of vascular smooth muscle.
Clinical Studies (6)
There is no peer-reviewed literature on Cock Bombs (Sildenafil 50 + Tadalafil 20) as a combination. What follows is the literature on each component separately:
- Sobre Sildenafilo: Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. (Goldstein I, et al. · N Engl J Med · 1998) PMID 9580646.
- Sobre Tadalafilo: Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. (Brock GB, et al. · J Urol · 2002) PMID 12352386.
- Sobre Sildenafilo: Sildenafil citrate therapy for pulmonary arterial hypertension. (Galiè N, et al. · N Engl J Med · 2005) PMID 16291984.
- Sobre Tadalafilo: Tadalafil pharmacokinetics in healthy subjects. (Forgue ST, et al. · Br J Clin Pharmacol · 2006) PMID 16487221.
- Sobre Sildenafilo: Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension. (Hoeper MM, et al. · Circulation · 2024) PMID 38752352.
- Sobre Tadalafilo: Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, double-blind, placebo-controlled trial. (Porst H, et al. · Eur Urol · 2011) PMID 21871706.
Warnings
Cock Bombs (Sildenafil 50 + Tadalafil 20) is a compound for research use only (RUO); the following warnings and handling considerations apply to its use in the laboratory:
- Product exclusively for use in laboratory research
- Requires handling under biosafety protocols
- It may potentiate the hypotensive effect of nitric oxide donors
- Critical interaction with organic nitrates and nitrites
- Concomitant use with guanylate cyclase stimulators
- Models with severe hepatic or renal insufficiency
- Presence of preexisting cardiovascular pathologies in study subjects
Technical data
- CAS
- 139755-83-2 / 171596-29-5
- Molecular formula
- C22H30N6O4S (Sildenafil) / C22H19N3O4 (Tadalafil)
- Compound type
- blend
- Storage
- 15-30°C in a dry, cool place
- Shelf life (lyophilized)
- 36 months
- Shelf life (reconstituted)
- Not applicable (solid formulation)
- Light-sensitive
- No
Frequently asked questions about Cock Bombs (Sildenafil 50 + Tadalafil 20)
What is Cock Bombs (Sildenafil 50 + Tadalafil 20)?
Research compound that combines Sildenafil (50 mg) and Tadalafil (20 mg) in an oral formulation. It acts as a dual phosphodiesterase-5 (PDE5) inhibitor for studying its effect on vascular hemodynamics.
What is the mechanism of action of Cock Bombs (Sildenafil 50 + Tadalafil 20)?
Competitive and selective inhibition of the enzyme phosphodiesterase type 5, enhancing cGMP signaling to induce relaxation of vascular smooth muscle.
What is Cock Bombs (Sildenafil 50 + Tadalafil 20) being investigated for?
In preclinical research, Cock Bombs (Sildenafil 50 + Tadalafil 20) is studied mainly in: Research on the modulation of intracavernosal blood flow; Study of nitric oxide-mediated tissue relaxation; Analysis of peripheral vascular resistance in lyophilized models. Material exclusively for scientific research.
What are the chemical properties of Cock Bombs (Sildenafil 50 + Tadalafil 20)?
CAS number 139755-83-2 / 171596-29-5.
How is Cock Bombs (Sildenafil 50 + Tadalafil 20) stored?
Storage conditions: 15-30°C in a dry, cool place; lyophilized stability: 36 months; once reconstituted: Not applicable (solid formulation).
What routes of administration are studied for Cock Bombs (Sildenafil 50 + Tadalafil 20)?
The following are described in research models: Oral (Research), Intragastric (Animal models). Use is exclusively for scientific research.