Dapoxetine: Scientific Profile

Publicado el 25 de julio de 2026 · Actualizado el 14 de septiembre de 2026

Short-acting selective serotonin reuptake inhibitor (SSRI).

Dapoxetine (English name Dapoxetine; CAS 129938-20-1) is a synthetic NON-peptide compound belonging to the class of selective serotonin reuptake inhibitors (SSRIs). With molecular formula C21H23NO and an approximate molecular weight of 305.42 g/mol, it differs from other SSRIs by a short-acting pharmacokinetic profile: in research models it shows rapid absorption and equally rapid elimination, which sets it apart from chronically used SSRIs.

Dapoxetine's mechanism of action is based on the inhibition of the serotonin reuptake transporter (SERT) in the synaptic cleft, which increases serotonin availability and potentiates its signaling. Its rapid absorption and clearance kinetics is the characteristic that has focused interest on its study, since it gives rise to a transient exposure pattern distinct from that of conventional SSRIs.

In the research setting, Dapoxetine is used as a tool for studying serotonergic neurotransmission, the pharmacology of the SERT transporter, and short-acting SSRI models. It is a useful comparator against long-acting SSRIs in pharmacokinetic and pharmacodynamic studies.

Dapoxetine is supplied in the presentation indicated for its stable storage, protected from light and moisture according to the protocol. This product is offered exclusively as a research reagent (research use only): it is not intended for the diagnosis, prevention or treatment of any disease, nor for human or veterinary consumption.