DSIP: Scientific Profile
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Endogenous neuromodulatory nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu; CAS 62568-57-4). Orphan neuropeptide that enhances delta (slow-wave) EEG activity. Reagent for research (RUO).
DSIP (Delta Sleep-Inducing Peptide; English name Delta Sleep-Inducing Peptide; CAS 62568-57-4) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. With the molecular formula C35H48N10O15S and a molecular weight of approximately 848.8 g/mol, it is a short peptide originally isolated from sleep studies in animal models, from which it takes its name owing to its association with delta wave activity.
From a structural standpoint, DSIP is a linear chain of nine amino acids. Despite its name, its exact functional classification and its specific receptor remain under study: in research it behaves more like a modulatory peptide with broad effects than like a ligand for a single well-defined target.
DSIP's mechanism of action is not fully characterized. In preclinical models its relationship with the regulation of sleep and circadian rhythms has been studied, as well as a possible involvement in the modulation of stress responses and in neuroendocrine circuits. Because of its ability to cross biological barriers and its relative stability, it has been used as a tool to explore peptide signaling in the central nervous system in research models.
In research, DSIP is used as a tool for studying the regulation of sleep and circadian rhythms, peptide neuromodulation, and neuroendocrine responses to stress in experimental models.
DSIP is supplied as a lyophilized powder for reconstitution. Frozen storage protected from light is recommended, along with reconstitution using the sterile diluent indicated in the protocol. This product is offered exclusively as a research reagent (research use only): it is not intended for the diagnosis, prevention or treatment of any disease, nor for human or veterinary consumption.
Mechanism of action
DSIP modulates circadian rhythms and promotes cerebral delta waves associated with restorative deep sleep.
Mechanism summary
An orphan neuropeptide with no identified high-affinity receptor. After central administration it enhances the delta activity (slow waves) of the EEG, a property that gives rise to its name. Its precise molecular targets remain uncharacterized; it is used as a research tool in sleep regulation.
Clinical Studies (6)
- Delta-sleep-inducing peptide (DSIP): a review (Graf MV, et al. · Neuroscience & Biobehavioral Reviews · 1984) — Review of DSIP: isolation, characterization and available evidence on its reported effects on sleep. PMID 6145137.
- Synthetic delta-sleep-inducing peptide improves sleep in insomniacs. (Schneider-Helmert D, et al. · Lancet · 1981) PMID 6112579.
- Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial. (Backmund M, et al. · J Clin Psychopharmacol · 1998) PMID 9617990.
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide (Schoenenberger, et al. · Proceedings of the National Academy of Sciences (PNAS) · 1977) PMID 265572.
- A clinical trial with DSIP (Kaeser · European Neurology · 1984) PMID 6391926.
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study (Bes, et al. · Neuropsychobiology · 1992) PMID 1299794.
Warnings
DSIP is a compound exclusively for research use (RUO); the following warnings and handling considerations apply to its use in the laboratory:
- Use before sleep
- Short cycles recommended
- Models with known hypersensitivity to DSIP or excipients
- Pregnant or lactating models (insufficient data)
- Models under 18 years old
- Models with uncontrolled psychiatric disorders
- Co-administration with CNS depressants without supervision
- Models with untreated severe sleep apnea
Technical data
- CAS
- 62568-57-4
- Molecular formula
- C35H48N10O15
- Molecular weight
- 848.89 Da
- Compound type
- peptide
- Storage
- -20 °C liofilizado; 2-8 °C reconstituido
- Shelf life (lyophilized)
- 24 months
- Shelf life (reconstituted)
- 21 days refrigerated
- Light-sensitive
- Sí
Available for research
DSIP is available as a research-use-only (RUO) reagent with HPLC-verified purity and a per-batch COA:
Frequently asked questions about DSIP
What is DSIP?
Endogenous neuromodulatory nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu; CAS 62568-57-4). Orphan neuropeptide that enhances delta (slow-wave) EEG activity.
What is the mechanism of action of DSIP?
Orphan neuropeptide with no identified high-affinity receptor. After central administration it enhances delta (slow-wave) EEG activity, a property that gives it its name.
What is DSIP researched for?
In preclinical research, DSIP is studied mainly in: Delta-phase induction; Modulation of the HPA axis; Reduction of cortisol. Material for scientific research use only.
What are the chemical properties of DSIP?
Molecular formula C35H48N10O15; molecular weight 848.89 Da; CAS number 62568-57-4.
How is DSIP stored?
Condiciones de conservación: -20 °C liofilizado; 2-8 °C reconstituido; estabilidad liofilizado: 24 meses; una vez reconstituido: 21 días refrigerado; protéjase de la luz.
What routes of administration are studied for DSIP?
In the research models the following are described: Subcutaneous, Intranasal. Use is exclusively for scientific research.