HGH: Scientific Profile
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Recombinant human growth hormone (somatropin, rhGH) of 191 amino acids, identical in sequence to endogenous pituitary somatotropin. GHR receptor agonist for research use (RUO). CAS 12629-01-5.
Somatropin (recombinant human growth hormone, rhGH or somatotropin) is a 191-amino-acid peptide hormone produced in E. coli by recombinant DNA technology, identical in sequence to the GH synthesized by the anterior pituitary (CAS 12629-01-5; formula C990H1528N262O300S7; molecular mass ~22124 Da). It belongs to the somatotropin class of peptide hormones and acts as an agonist of the growth hormone receptor (GHR). Its mechanism consists of GHR dimerization, which activates the tyrosine kinase JAK2 and the transcription factor STAT5b, and induces downstream MAPK/ERK and PI3K/Akt signaling, raising hepatic IGF-1 production. In in vitro and preclinical models it is used to study the GH/IGF-1 axis, somatotropic signaling, protein synthesis, lipolysis, body composition, and tissue regeneration. Reagent intended exclusively for research use only (RUO).
Mechanism of action
HGH acts through GH receptors in the liver and peripheral tissues, stimulating the production of IGF-1 that mediates many of its anabolic effects.
Mechanism summary
Growth hormone receptor (GHR) agonist: it induces the dimerization of the receptor and activates the JAK2-STAT5b pathway, with downstream MAPK/ERK and PI3K/Akt signaling, raising the hepatic production of IGF-1 and stimulating cell growth and metabolism.
Estudios Clínicos (10)
- Effects of Growth Hormone on Body Composition (Rudman D, et al. · New England Journal of Medicine · 1990) — Classic study on the effects of GH on body composition in older adults. PMID 2355952.
- Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome. (Mohamed S, et al. · Cochrane Database Syst Rev · 2019) PMID 31684688.
- Efficacy, safety, quality of life, adherence and cost-effectiveness of long-acting growth hormone replacement therapy compared to daily growth hormone in children with growth hormone deficiency: A systematic review and meta-analysis. (Mameli C, et al. · Pharmacol Res · 2023) PMID 37236413.
- Multicentre clinical trial of authentic recombinant somatropin in growth hormone deficiency (Bierich · Acta Paediatrica Scandinavica Supplement · 1987) PMID 3324634.
- Antigenicity and efficacy of authentic sequence recombinant human growth hormone (somatropin): first-year experience in the United Kingdom (Buzi, et al. · Clinical Endocrinology · 1989) PMID 2691122.
- Recombinant DNA produced somatropin in the treatment of prepubertal growth hormone deficient children (Chang, et al. · Zhonghua Yi Xue Za Zhi (Chinese Medical Journal, Free China ed.) · 1991) PMID 1848467.
- Evaluation of the safety and efficacy of biosimilar recombinant growth hormone in children with growth hormone deficiency: non-inferiority, randomized, parallel, multicentric and Phase III trial (Zaeri, et al. · Expert Opinion on Drug Safety · 2025) PMID 38682328.
- Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone (Wu, et al. · Biochemistry and Molecular Biology International · 1993) PMID 8358331.
- Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide (Natera, et al. · Biochemistry and Molecular Biology International · 1994) PMID 7987248.
- Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells (Habibullah, et al. · Drug Design, Development and Therapy · 2022) PMID 35783198.
Warnings
HGH is a compound exclusively for research use (RUO); the following warnings and handling considerations apply to its use in the laboratory:
- Supervised medical use required
- Active malignancy
- Diabetic retinopathy
- Recent surgery
Technical data
- CAS
- 12629-01-5
- Molecular formula
- C990H1528N262O300S7
- Molecular weight
- 22124 Da
- Compound type
- hormone
- Storage
- -20 °C liofilizado; 2-8 °C reconstituido
- Shelf life (lyophilized)
- 24 months
- Shelf life (reconstituted)
- 28 days refrigerated
- Light-sensitive
- Sí
Available for research
HGH is available as a research reagent (RUO):
Frequently asked questions about HGH
What is HGH?
Recombinant human growth hormone (somatropin, rhGH) of 191 amino acids, identical in sequence to endogenous pituitary somatotropin. GHR receptor agonist for research (RUO).
What is the mechanism of action of HGH?
Growth hormone receptor (GHR) agonist: it induces the dimerization of the receptor and activates the JAK2-STAT5b pathway, with downstream MAPK/ERK and PI3K/Akt signaling, raising the hepatic production of IGF-1 and stimulating cell growth and metabolism.
What is HGH researched for?
In preclinical research, HGH is studied mainly in: Protein synthesis; Lipolysis; Tissue regeneration. Material for scientific research use only.
What are the chemical properties of HGH?
Molecular formula C990H1528N262O300S7; molecular weight 22124 Da; CAS number 12629-01-5.
How is HGH stored?
Condiciones de conservación: -20 °C liofilizado; 2-8 °C reconstituido; estabilidad liofilizado: 24 meses; una vez reconstituido: 28 días refrigerado; protéjase de la luz.
What routes of administration are studied for HGH?
In research models the following are described: Subcutaneous, Intramuscular. Use is exclusively for scientific research.