Brain Peptide Complex: Scientific Profile
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Cerebrolysin (CAS 12656-61-0): a neuropeptide preparation and pleiotropic neurotrophic drug. A mixture of low-molecular-weight peptides (< 10 kDa) and free amino acids that mimics BDNF, NGF and CNTF. Reagent for research.
Cerebrolysin (CAS 12656-61-0) is a neuropeptide preparation obtained by enzymatic hydrolysis of purified porcine brain tissue, considered a pleiotropic neurotrophic drug (a mixture, not a single molecule). Its composition combines a low-molecular-weight peptide fraction (< 10 kDa, approximately 25% of dry weight) with free amino acids (approximately 75% of dry weight). At the mechanistic level, it mimics the action of the neurotrophins BDNF, NGF, and CNTF and interacts with the receptor tyrosine kinases TrkB (via BDNF) and TrkA (via NGF), modulating synaptic plasticity and neuroprotection processes; it crosses the blood-brain barrier. The associated preclinical and in vitro research areas include acute ischemic stroke, mild cognitive impairment, vascular dementia, and Alzheimer's disease. It is distributed exclusively as a research-use-only (RUO) reagent: reconstitute in sterile water or saline solution and store at 2-8 C protected from light.
Mechanism of action
The Brain Peptide Complex acts through multiple complementary mechanisms:
- Modulation of neurotransmitters: Optimiza la señalización dopaminérgica, serotoninérgica y colinérgica
- Increase in neurotrophic factors: Estimula la producción de BDNF (Brain-Derived Neurotrophic Factor) y NGF
- Neuroplasticity: Promueve la formación de nuevas conexiones sinápticas y potenciación a largo plazo (LTP)
- Neuroprotection: Protege contra estrés oxidativo y excitotoxicidad glutamatérgica
- Cerebral blood flow: Improves microcirculation and delivery of oxygen/glucose to the brain
- Modulation of the HPA axis: Reduces the negative impact of cortisol on cognitive function
Mechanism summary
It mimics the action of the neurotrophins BDNF, NGF, and CNTF and interacts with the tyrosine kinase receptors TrkB (BDNF) and TrkA (NGF), modulating synaptic plasticity and neuroprotection. It crosses the blood-brain barrier.
Clinical Studies (4)
- Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial (Muresanu, et al. · Stroke · 2016) PMID 26564102.
- A 28-week, double-blind, placebo-controlled study with Cerebrolysin in patients with mild to moderate Alzheimer's disease (Ruether, et al. · International Clinical Psychopharmacology · 2001) PMID 11552768.
- Cerebrolysin in mild-to-moderate Alzheimer's disease: a meta-analysis of randomized controlled clinical trials (Gauthier, et al. · Dementia and Geriatric Cognitive Disorders · 2015) PMID 25832905.
- Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials (Bornstein, et al. · Neurological Sciences · 2018) PMID 29248999.
Warnings
Brain Peptide Complex is a research-use-only (RUO) compound; the following warnings and handling considerations apply to its laboratory use:
- For research use only
- Do not use without supervision
- Cycle use to maintain effectiveness
- Seizure disorders
- Use of MAOIs
- Pregnancy and lactation
Technical data
- CAS
- 12656-61-0
- Compound type
- peptide_blend
- Storage
- -20 °C liofilizado; 2-8 °C reconstituido
- Shelf life (lyophilized)
- 24 months
- Shelf life (reconstituted)
- 28 days refrigerated
- Light-sensitive
- No
Available for research
Brain Peptide Complex is available as a research reagent (RUO):
Frequently asked questions about Brain Peptide Complex
What is Brain Peptide Complex?
Cerebrolysin (CAS 12656-61-0): a neuropeptide preparation and pleiotropic neurotrophic drug. A mixture of low-molecular-weight peptides (< 10 kDa) and free amino acids that mimics BDNF, NGF, and CNTF.
What is the mechanism of action of Brain Peptide Complex?
It mimics the action of the neurotrophins BDNF, NGF, and CNTF and interacts with the tyrosine kinase receptors TrkB (BDNF) and TrkA (NGF), modulating synaptic plasticity and neuroprotection. It crosses the blood-brain barrier.
What is Brain Peptide Complex researched for?
In preclinical research, Brain Peptide Complex is studied mainly in: BDNF/NGF expression; Synaptic plasticity; Cerebral perfusion. Material for scientific research use only.
What are the chemical properties of Brain Peptide Complex?
CAS number 12656-61-0.
How is Brain Peptide Complex stored?
Condiciones de conservación: -20 °C liofilizado; 2-8 °C reconstituido; estabilidad liofilizado: 24 meses; una vez reconstituido: 28 días refrigerado.
What routes of administration are studied for Brain Peptide Complex?
In the research models the following are described: Subcutaneous, Intranasal. Use is exclusively for scientific research.