Ostarine (MK-2866): Scientific Profile
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Ostarine (MK-2866) is a non-steroidal selective androgen receptor modulator (SARM), used in research models for the study of muscle and bone anabolism without systemic androgenic activity.
Ostarine, technically identified as Enobosarm or MK-2866, is a selective androgen receptor ligand (SARM) developed for research into catabolic conditions. Unlike traditional anabolic steroids, this compound exhibits significant tissue selectivity, directing its biological activity toward muscle fibers and bone mineral density through high-affinity binding to AR androgen receptors.
In laboratory settings, MK-2866 has demonstrated the ability to stimulate protein synthesis and improve nitrogen retention in skeletal tissue. Due to its non-steroidal chemical structure, it does not undergo aromatization to estrogens or reduction by 5-alpha reductase to dihydrotestosterone, which allows the study of anabolic processes with a reduced incidence of virilizing side effects in experimental models.
Current research with Ostarine focuses on the quantification of its effects on the increase of functional lean mass and bone strength. Its potential has been documented in the prevention of muscle atrophy induced by sarcopenia or disuse, as well as in the acceleration of tissue recovery after skeletal trauma in study subjects, while maintaining a low affinity for receptors in organs such as the prostate and liver.
Mechanism of action
Ostarine (MK-2866/enobosarm) is a non-steroidal selective androgen receptor modulator (SARM) that binds to the androgen receptor with high affinity (Ki ~3-5 nM) and acts as a tissue-selective partial agonist. By binding to these receptors in muscle and bone tissue, it promotes the transcription of genes necessary for the synthesis of contractile proteins; its selectivity lies in the differential recruitment of transcriptional co-activators, with a partial agonist or antagonist response in androgenic tissues such as the prostate.
Mechanism summary
Selective agonist of androgen receptors that promotes protein anabolism in musculoskeletal tissue without aromatization.
Clinical Studies (5)
- Ostarine blunts the effect of endurance training on submaximal endurance in rats (Vasilev V et al. · Naunyn-Schmiedeberg's archives of pharmacology · 2024) PMID 38451281.
- Sex-specific cytotoxicity of ostarine in cardiomyocytes (Leciejewska N et al. · Molecular and cellular endocrinology · 2023) PMID 37543162.
- Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles (Leciejewska N et al. · International journal of molecular sciences · 2022) PMID 35457222.
- The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial (Dalton, et al. · Journal of Cachexia, Sarcopenia and Muscle · 2011) PMID 22031847.
- Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial (Dobs, et al. · The Lancet Oncology · 2013) PMID 23499390.
Warnings
Ostarine (MK-2866) is a research-use-only (RUO) compound; the following warnings and handling considerations apply to its laboratory use:
- Exclusive use for laboratory research
- Requires monitoring of lipid profiles in study subjects
- May require post-study recovery protocols in animal models
- Research models with preexisting hepatopathies
- Experimental subjects with hormone-dependent tumors
- Research in subjects with severe dyslipidemia
- Pregnancy and lactation in animal models
Technical data
- CAS
- 841205-47-8
- Molecular formula
- C19H14F3N3O3
- Molecular weight
- 389.33 Da
- Compound type
- sarm
- Storage
- 15-30°C in a dry place
- Shelf life (lyophilized)
- 36 months
- Shelf life (reconstituted)
- Not applicable (Tablets/Capsules)
- Light-sensitive
- No
Available for research
Ostarine (MK-2866) is available as a research reagent (RUO):
Frequently asked questions about Ostarine (MK-2866)
What is Ostarine (MK-2866)?
Ostarine (MK-2866) is a non-steroidal selective androgen receptor modulator (SARM), used in research models for the study of muscle and bone anabolism without systemic androgenic activity.
What is the mechanism of action of Ostarine (MK-2866)?
Selective agonist of androgen receptors that promotes protein anabolism in musculoskeletal tissue without aromatization.
What is Ostarine (MK-2866) being researched for?
In preclinical research, Ostarine (MK-2866) is studied mainly in: Research on the preservation of lean mass; Modulation of bone mineral density metabolism; Study of skeletal protein synthesis. Material exclusively for scientific research.
What are the chemical properties of Ostarine (MK-2866)?
Molecular formula C19H14F3N3O3; molecular weight 389.33 Da; CAS number 841205-47-8.
How is Ostarine (MK-2866) stored?
Storage conditions: 15-30°C in a dry place; lyophilized stability: 36 months; once reconstituted: Not applicable (Tablets/Capsules).
What routes of administration are studied for Ostarine (MK-2866)?
In research models the following are described: Oral. Use is exclusively for scientific research.