Relaxation PM: Scientific Profile
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Mixture formulated for the study of the modulation of GABAergic axes and the regulation of the circadian cycle in research models. It combines amino-acid precursors and neuroendocrine agents for physiological analysis.
Relaxation PM is a formulation designed for academic and clinical research on the modulation of the central nervous system. The compound integrates key components such as GABA, Melatonin, L-Arginine, and L-Glutamine, allowing the analysis of biochemical synergies in the resting phase. Its application in study models facilitates the observation of the dynamics between inhibitory neurotransmitters and nocturnal metabolic homeostasis.
Research with this compound focuses on the impact of exogenous melatonin on MT1 and MT2 receptor signaling, as well as the role of glutamine and arginine in the biosynthesis of nitrogenous compounds during periods of physical inactivity. Its properties allow for the examination of the mitigation of oxidative stress markers and the optimization of recovery processes at the cellular level.
This product is exclusively for use in laboratory and research settings. The study of its molecular stability under circadian variations provides critical data on neuroprotection and the regulation of smooth muscle tone through the nitric oxide pathway, mediated by the amino-acid components of the formulation.
Mechanism of action
The mechanisms derive from its two components: melatonin acts as an agonist of the MT1/MT2 melatonin receptors (G-protein coupled), regulating the circadian rhythm, sleep, and immunomodulatory processes; L-Arginine functions as a substrate of nitric oxide synthase (NOS), promoting nitric oxide production, vasodilation, and nutrient transport during the resting phase.
Mechanism summary
Modulation of GABAergic and MT1/MT2 receptors combined with nitric oxide biosynthesis for the study of sleep-wake cycle homeostasis.
Clinical Studies (6)
There is no peer-reviewed literature on Relaxation PM as a combination. What follows is the literature on each component separately:
- Sobre GABA: Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial. (Byun JI, et al. · J Clin Neurol · 2018) PMID 29856155.
- Sobre Melatonina: Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis. (Cruz-Sanabria F, et al. · J Pineal Res · 2024) PMID 38888087.
- Sobre GABA: Efficacy and Safety of Low-Dose Gamma-Aminobutyric Acid From Unpolished Rice Germ as a Health Functional Food for Promoting Sleep: A Randomized, Double-Blind, Placebo-Controlled Trial. (Yoon S, et al. · J Clin Neurol · 2022) PMID 35796273.
- Sobre Melatonina: Human phase response curves to three days of daily melatonin: 0.5 mg versus 3.0 mg. (Burgess HJ, et al. · J Clin Endocrinol Metab · 2010) PMID 20410229.
- Sobre GABA: Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. (Yamatsu A, et al. · Food Sci Biotechnol · 2016) PMID 30263304.
- Sobre Melatonina: Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses. (Choi K, et al. · Sleep Med Rev · 2022) PMID 36179487.
Warnings
Relaxation PM is a research-use-only (RUO) compound; the following warnings and handling considerations apply to its laboratory use:
- Do not administer before protocols requiring motor activity
- Dose adjustment is required in renal insufficiency studies
- Avoid combination with other CNS depressant agents
- Interference with anticonvulsant drugs under study
- Hypersensitivity to arginine precursors
- Pregnancy and lactation in pregnant animal models
Technical data
- Compound type
- blend
- Storage
- -20 °C liofilizado; 2-8 °C reconstituido
- Shelf life (lyophilized)
- N/A
- Shelf life (reconstituted)
- 90 days after opening
- Light-sensitive
- No
Frequently asked questions about Relaxation PM
What is Relaxation PM?
Mixture formulated for the study of the modulation of GABAergic axes and the regulation of the circadian cycle in research models. It combines amino-acid precursors and neuroendocrine agents for physiological analysis.
What is the mechanism of action of Relaxation PM?
Modulation of GABAergic and MT1/MT2 receptors combined with nitric oxide biosynthesis for the study of sleep-wake cycle homeostasis.
What is Relaxation PM researched for?
In preclinical research, Relaxation PM is studied mainly in: Modulation of the circadian rhythm in biological models; Research on the reduction of neuronal excitability; Study of nocturnal nitric oxide synthesis. Material exclusively for scientific research.
How is Relaxation PM stored?
Condiciones de conservación: -20 °C liofilizado; 2-8 °C reconstituido; estabilidad liofilizado: N/A; una vez reconstituido: 90 días tras apertura.
What routes of administration are studied for Relaxation PM?
In the research models the following are described: Subcutaneous, Oral. Use is exclusively for scientific research.
What precautions should be considered with Relaxation PM?
Relaxation PM is material for research use only. Do not administer before protocols that require motor activity. Dose adjustment is required in studies of renal insufficiency.