Shred: Scientific Profile
Publicado el · Actualizado el
Research formulation that integrates lipotropic agents and B vitamins for the study of lipid metabolism and the mobilization of fatty acids in preclinical models.
Shred is a compound designed for the analysis of metabolic efficiency, combining essential amino acids and enzymatic cofactors. Its composition includes L-carnitine, a critical transporter of long-chain fatty acids into the mitochondrial matrix for their subsequent beta-oxidation. In the research setting, this compound is used to observe the rate of lipid degradation in response to controlled metabolic stimuli.
The inclusion of lipotropic agents such as choline, inositol, and methionine allows the study of lipid export from hepatic tissue, preventing the accumulation of triglycerides in models of induced steatosis. These components act synergistically to facilitate the formation of very-low-density lipoproteins (VLDL), thereby optimizing the transport of systemic lipids for energy utilization.
Likewise, Shred incorporates methylcobalamin and pyridoxine, facilitating the study of methylation pathways and homocysteine metabolism. This combination is fundamental in research protocols that seek to evaluate the optimization of protein synthesis and the maintenance of energy homeostasis under simulated caloric-deficit conditions in laboratory settings.
Mechanism of action
The central mechanism of action lies in facilitating the transport of energy substrates. L-carnitine mediates the entry of fatty acids across the mitochondrial membrane via the carnitine palmitoyltransferase shuttle system. Simultaneously, the lipotropic complex (methionine/choline/inositol) acts as a methyl-group donor and phospholipid precursor, essential for the integrity of cell membranes and the hepatic processing of fats. Supplementation with B12 and B6 optimizes the Krebs cycle and neurotransmitter synthesis, regulating the efficiency of basal energy expenditure.
Mechanism summary
It works by optimizing the mitochondrial carnitine shuttle and hepatic lipid export through methyl-donor agents and enzymatic cofactors.
Clinical Studies (6)
There is no peer-reviewed literature on Shred as a combination. What follows is the literature on each component separately:
- Sobre L-Carnitina: Carnitine transport and fatty acid oxidation. (Longo N, et al. · Biochim Biophys Acta · 2016) PMID 26828774.
- Sobre L-Metionina: Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. (Plaisance EP, et al. · J Clin Endocrinol Metab · 2011) PMID 21346062.
- Sobre Inositol: Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. (Nestler JE, et al. · N Engl J Med · 1999) PMID 10219066.
- Sobre Colina: Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. (Buchman AL, et al. · JPEN J Parenter Enteral Nutr · 2001) PMID 11531217.
- Sobre Vitamina B12: Vitamin B12 deficiency (Stabler, et al. · The New England Journal of Medicine · 2013) PMID 23301732.
- Sobre L-Carnitina: Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. (Wall BT, et al. · J Physiol · 2011) PMID 21224234.
Warnings
Shred is a compound exclusively for research use (RUO); the following warnings and handling considerations apply to its use in the laboratory:
- For exclusive use in research settings
- Requires strict aseptic techniques for parenteral administration
- Monitor renal function in models predisposed to nephropathy
- Models with a history of idiopathic seizures
- Research subjects with chronic renal insufficiency
- Presence of documented hypersensitivity to cobalamin
- Models with obstructive disorders of the biliary tract
Technical data
- Compound type
- blend
- Storage
- 15-25°C protected from light
- Shelf life (lyophilized)
- Not applicable
- Shelf life (reconstituted)
- 24 months in sterile solution
- Light-sensitive
- Sí
Frequently asked questions about Shred
What is Shred?
Research formulation that integrates lipotropic agents and B vitamins for the study of lipid metabolism and the mobilization of fatty acids in preclinical models.
What is the mechanism of action of Shred?
It works by optimizing the mitochondrial carnitine shuttle and hepatic lipid export through methyl-donor agents and enzymatic cofactors.
What is Shred researched for?
In preclinical research, Shred is studied mainly in: Research on the mobilization of fatty acids; Study of the prevention of hepatic steatosis; Analysis of the modulation of energy expenditure. Material exclusively for scientific research.
How is Shred stored?
Storage conditions: 15-25°C protected from light; lyophilized stability: Not applicable; once reconstituted: 24 months in sterile solution; protect from light.
What routes of administration are studied for Shred?
In research models the following are described: Subcutaneous, Intramuscular. Use is exclusively for scientific research.
What precautions should be considered with Shred?
Shred is material for research use only. For use only in research settings. It requires strict aseptic techniques for parenteral administration.