SLU-PP-332 + BAM-15 Capsule Blend: Scientific Profile
Publicado el · Actualizado el
Experimental combination of the ERR-α agonist SLU-PP-332 and the mitochondrial uncoupler BAM-15. Designed for the study of aerobic metabolism and thermogenesis in molecular research models.
The compound SLU-PP-332 + BAM-15 Capsule Blend represents a dual delivery system for the advanced study of cellular bioenergetics. SLU-PP-332 acts as an agonist of the estrogen-related orphan receptors (ERR-α, ERR-β, and ERR-γ), which are key regulators in the transcription of genes involved in fatty acid transport and mitochondrial biogenesis. Its application in research focuses on evaluating the enhancement of the oxidative capacity of skeletal muscle tissue.
Simultaneously, BAM-15 (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) acts as a highly selective mitochondrial uncoupler. Unlike other agents, BAM-15 dissipates the proton gradient across the inner mitochondrial membrane without altering the plasma membrane potential, which allows the study of the increase in cellular energy expenditure and the oxidation of carbon substrates without inducing the systemic toxicity associated with non-specific uncouplers.
This molecular synergy allows researchers to observe the interaction between the transcriptional activation of oxidative metabolism and the increase in metabolic flux. It is a critical tool for protocols that analyze technical weight reduction and metabolic resistance in preclinical research contexts on metabolic syndrome and mitochondrial dysfunction.
Mechanism of action
SLU-PP-332 selectively activates the ERR receptors, promoting a gene expression program that mimics the effects of endurance training, increasing mitochondrial density. In parallel, BAM-15 facilitates the transport of protons across the mitochondrial membrane, uncoupling the electron transport chain from ATP synthesis, which forces the cell to increase oxygen consumption and the rate of lipolysis to compensate for the energy deficit.
Mechanism summary
Synergy of an ERR receptor agonist for mitochondrial biogenesis and a selective mitochondrial uncoupler for the increase of metabolic flux and oxygen consumption.
Clinical Studies (6)
There is no peer-reviewed literature on SLU-PP-332 + BAM-15 Capsule Blend as a combination. What follows is the literature for each component separately:
- About SLU-PP-332: Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity (Billon, et al. · ACS Chemical Biology · 2023) PMID 36988910.
- About BAM-15: Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane (Kenwood, et al. · Molecular Metabolism · 2014) PMID 24634817.
- About SLU-PP-332: A Synthetic ERR Agonist Alleviates Metabolic Syndrome (Billon, et al. · Journal of Pharmacology and Experimental Therapeutics · 2024) PMID 37739806.
- About BAM-15: Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice (Alexopoulos, et al. · Nature Communications · 2020) PMID 32409697.
- About SLU-PP-332: Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function (Xu, et al. · Circulation · 2024) PMID 37961903.
- About BAM-15: BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control (Axelrod, et al. · EMBO Molecular Medicine · 2020) PMID 32519812.
Warnings
SLU-PP-332 + BAM-15 Capsule Blend is a research-use-only (RUO) compound; the following warnings and handling considerations apply to its laboratory use:
- Exclusive use in research laboratories
- Requires constant monitoring of the specimen's temperature
- Handling under chemical safety protocols
- Models with pre-existing malignant hyperthermia
- Research subjects with renal insufficiency
- Presence of hypertrophic cardiomyopathies in the study model
Technical data
- CAS
- 210302-17-3 (BAM-15) / 303760-60-3 (SLU-PP-332)
- Molecular formula
- C16H10F2N6O (BAM-15) / C18H14N2O2 (SLU-PP-332)
- Compound type
- blend
- Storage
- 15-25°C in a dry place
- Shelf life (lyophilized)
- 24 months
- Shelf life (reconstituted)
- Not applicable (encapsulated formulation)
- Light-sensitive
- No
Available for research
SLU-PP-332 + BAM-15 Capsule Blend is available as a research reagent (RUO):
Frequently asked questions about SLU-PP-332 + BAM-15 Capsule Blend
What is SLU-PP-332 + BAM-15 Capsule Blend?
Experimental combination of the ERR-α agonist SLU-PP-332 and the mitochondrial uncoupler BAM-15. Designed for the study of aerobic metabolism and thermogenesis in molecular research models.
What is the mechanism of action of SLU-PP-332 + BAM-15 Capsule Blend?
Synergy of an ERR receptor agonist for mitochondrial biogenesis and a selective mitochondrial uncoupler for the increase of metabolic flux and oxygen consumption.
What is SLU-PP-332 + BAM-15 Capsule Blend researched for?
In preclinical research, SLU-PP-332 + BAM-15 Capsule Blend is studied mainly in: Research on the modulation of mitochondrial biogenesis; Study of the increase in basal energy expenditure; Evaluation of weight reduction in models of metabolic resistance. Material exclusively for scientific research.
What are the chemical properties of SLU-PP-332 + BAM-15 Capsule Blend?
CAS Number 210302-17-3 (BAM-15) / 303760-60-3 (SLU-PP-332).
How is SLU-PP-332 + BAM-15 Capsule Blend stored?
Storage conditions: 15-25°C in a dry place; lyophilized stability: 24 months; once reconstituted: Not applicable (encapsulated formulation).
What routes of administration are studied for SLU-PP-332 + BAM-15 Capsule Blend?
In research models the following are described: Oral. Use is exclusively for scientific research.