B7-33
B7-33 — reagent for research use (RUO).
Sizes and prices: 6 mg $3,150 MXN ($525 MXN per mg).
Buy B7-33 in Mexico: order online with nationwide shipping in 1-4 business days depending on zone and tracking number. Prices in Mexican pesos. Material for research use only.
FAQ
What is B7-33?
B7-33 is a peptide, a single-chain analog of relaxin-2 (H2), used as a reagent in research on fibrosis and remodeling of the extracellular matrix. It is marketed exclusively as a research reagent; it is not intended for therapeutic or diagnostic use.
What is the mechanism of action studied with B7-33?
In research models, B7-33 behaves as an agonist of the RXFP1 receptor, with signaling biased toward the pERK pathway, without activating the cAMP pathway associated with the hemodynamic effects of full relaxin. This pathway selectivity is one of the traits that make it of interest as a tool in studies of extracellular matrix remodeling.
How does B7-33 differ from full relaxin-2 (H2)?
Unlike native relaxin, which has interchain disulfide bridges, B7-33 is a single-chain analogue without those bridges, which simplifies its synthesis compared with native relaxin. This structural difference, together with its biased signaling toward the pERK pathway, distinguishes its research profile from that of the full molecule.
In what research lines is B7-33 used?
It is used in research on cardiac, renal and pulmonary fibrosis, as well as in extracellular matrix remodeling. Its use is limited to the scope of laboratory research.
How should this reagent be stored?
In its lyophilized 6 mg presentation, B7-33 must be stored at -20 °C. Once reconstituted, it is recommended to keep it between 2-8 °C and protected from light.
What is the CAS number of B7-33 and in what form is it presented?
The CAS number registered for this compound is 1818415-56-3. The form used in the certificate of analysis (COA) is the acetate salt.
Scientific references (3)
Peer-reviewed literature on B7-33, with its PubMed identifier when available:
- A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1 (Hossain, et al. · Chemical Science · 2016) PMID 30155023.
- B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice (Devarakonda, et al. · Journal of the American Heart Association · 2020) PMID 32295457.
- Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation (Welch, et al. · ACS Applied Materials & Interfaces · 2019) PMID 31713411.
See the full category catalog: Hormonal.