AICAR Oral
AICAR Oral — reactivo for research (RUO). Contenido revisado por el Dr. Jesús Jaramillo.
Technical data
- INN name
- Acadesine
- Development code
- GP-1-110
- CAS
- 2627-69-2
- Molecular formula
- C9H14N4O5
- Molecular weight
- 258.23 g/mol
Sizes and prices: 10 mg × 100 tablets $2,557 MXN ($256 MXN per mg).
Buy AICAR Oral in Mexico: order online with nationwide shipping in 1-4 business days depending on zone and tracking number. Prices in Mexican pesos. Material for research use only.
AICAR Oral is known internationally as Acadesine (INN name in English). Buy Acadesine in Mexico / buy Acadesine in Mexico: research reagent (RUO) and nationwide shipping.
AICAR Oral is also searched as: Acadesine (INN/USAN), Acadesina, AICA riboside, AICAr, NSC-105823, Z-riboside, GP-1-110.
FAQ
What is Oral AICAR?
AICAR Oral is the oral tablet presentation (10 mg × 100 tablets) of acadesine (AICAR or AICA riboside), a nucleoside analog identified by CAS number 2627-69-2 and molecular formula C9H14N4O5 (molecular weight 258.23 g/mol). It is a reagent intended exclusively for scientific research on the enzyme AMPK and cellular energy metabolism.
What is its mechanism of action?
At the biochemical level, acadesine is phosphorylated intracellularly to ZMP, a molecule that mimics AMP and binds to the regulatory (γ or Bateman) domain of AMPK, activating it allosterically without altering the AMP/ATP ratio. In preclinical studies this activation has been linked to the phosphorylation of the α subunit of AMPK and to processes such as fatty-acid oxidation and glucose uptake in muscle tissue.
What is it used for in research?
In preclinical research, acadesine is used to study mitochondrial biogenesis, fatty acid oxidation in obesity models, insulin-independent glucose uptake, and aerobic endurance in murine models. Its role in cellular protection against oxidative stress and ischemia has also been investigated. These applications correspond to in vitro and animal-model studies, not to clinical use in humans.
How should AICAR Oral be stored?
It must be stored between 15 and 25 °C, protected from light and humidity, and kept in its original closed container until use in the laboratory.
Does AICAR Oral have therapeutic or medical use?
No. AICAR Oral is a product for research use only; it has not been evaluated or approved by health authorities for human use or for therapeutic purposes. Its handling is intended for laboratory personnel in the context of scientific studies, not as a supplement or as a treatment.
Customer reviews
Average rating: 4.8 out of 5, based on 5 customer ratings.
I. P. — 5/5
The consistency of the batch relative to previous deliveries is confirmed, maintaining a precise dosing of 10mg per unit. The label contains legible technical information and the sealing of the vial ensures the absence of external contaminants. The transit time to the laboratory was 48 hours after the order.
R. O. — 4/5
The delivery was made within the established parameters, although the outer packaging showed minor pressure marks that did not affect the internal crystals. The solubility is adequate for handling in the experimental model, maintaining the transparency required for subsequent spectrophotometric analyses.
E. G. — 5/5
The technical-grade packaging protected the structural integrity of the vials during shipment. Adequate thermal stability of the lyophilized powder was observed. The reported dosing of 10mg is consistent with the gravimetric measurements performed in-house prior to the preclinical experimentation.
V. A. — 5/5
Reconstitution of the reagent in buffer solutions is carried out without the formation of visible aggregates. The absorption spectra obtained strictly match the certificate of analysis (COA) provided by the supplier. Material suitable for metabolic activation studies in research models.
I. P. — 5/5
The compound presents an HPLC-verified purity greater than 98% according to the attached laboratory report. Solubility in aqueous media is immediate, resulting in a clear solution free of cell sediment for the established in vitro protocol. The packaging maintained the integrity chain of the vial.
Scientific references (5)
Peer-reviewed literature on AICAR Oral, with its PubMed identifier where available:
- Cardiovascular and renal effects of 5-aminoimidazole-4-carboxyribonucleoside (AICAR) in the deoxycorticosterone acetate (DOCA)-salt rat model of hypertension (Dennis MR et al. · Life Sciences · 2025) PMID 40947048.
- Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy (Chandrasekaran K et al. · International journal of molecular sciences · 2024) PMID 39795939.
- AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review (Višnjić D et al. · Cells · 2021) PMID 34064363.
- 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? (Corton, et al. · European Journal of Biochemistry · 1995) PMID 7744080.
- AMPK and PPARdelta agonists are exercise mimetics (Narkar, et al. · Cell · 2008) PMID 18674809.
Full scientific profile: AICAR in the compendium — mechanism of action, studies and technical data sheet.
See the full category catalog: Orals.
Otras presentaciones de AICAR Oral
Guides and articles about AICAR Oral
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